PCOL350

ADME, an acronym for absorption, distribution, metabolism, and excretion is often the determining factor in whether drugs and chemicals generate the desired effect, no effect, or a harmful effect. PCOL 350 provides students with an overview of how drugs get into the tissues of the body and back out again, what happens along the way, and how things go wrong leading to specific and non-specific toxicities. Students will gain a broad understanding of the mechanisms of toxicity from oxidative damage to genotoxicity, assays and methods for assessing toxicity, and the details of ADME and physiology that lead to damage in specific organs.

017696

PCOL 406 is recommended.